Preface (XIII)1 - Introduction (1)1.1 - Introduction to the research1.2 - Overview of the dissertation2 - Background Information (7)2.1 - Chronic care in the Netherlands2.2 - Introduction to thrombosis2.3 - Technology acceptance3 - Literature and Conceptual Model (23)3.1 - Introduction3.2 - The concept of attitude in psychology3.3 - Theory of Reasoned Action (TRA)3.4 - Social Cognitive Theory (SCT)3.5 - Theory of Planned Behavior (TPB)3.6 - Introduction of conceptual TAM for patients4 - Methodology, Data-Analysis and Results (45)4.1 - Introduction4.2 - Method4.3 - Results4.4 - Summary of the mediation analyses4.5 - Discussion5 - General Discusssion (73)5.1 - Summary of the main findings5.2 - Contribution and implications5.3 - Recommendations for future research5.4 - ConclusionAppendices (85)List of References (117)Summary (137)Samenvatting (Summary in Dutch) (141)About the Author (145)It is common knowledge that the number of elderly people will increase in the coming years. According to the most recent predictions, this ageing society will not only affect and increase the demand for health care, but also health care providers as health care professionals themselves will retire in the near future.A possible solution for this problem would be to let patients manage their - chronic - disease at home by means of so-called e-health self-management. This allows patients to stay in contact with their health care professional while managing specific parts of their therapy by means of information and communication technology (ICT). Not only may this increase the wellbeing of patients, also the pressure on the health care system may be somewhat relieved.This research has investigated the most relevant factors that may affect patients’ acceptance of these e-health services. One of the outcomes is that not only patients’ performance expectancy of e-health services is relevant/crucial to their acceptance of e-health, but also their perceived quality of care and their highest educational level. As for future research, this study recommends additional research on patients’ acceptance over a longer period of time (longitudinal).Furthermore, considering the increasing freedom of choice with regard to health care insurance policies, therapies and hospitals, the understanding of ‘patient satisfaction’ should be improved. In this respect, the way in which patients come to a judgment based upon their experiences is especially important considering the increased relevance of patient satisfaction.