Table of Contents - 8[-]1. Introduction and outline of the thesis - 10[-]2. Isolated limb perfusion: what is the evidence for its use? - 18[-]3. Isolated limb perfusion for unresectable melanoma of the extremities - 32[-]4. Isolated limb perfusion prolongs the limb recurrence-free interval after several episodes of excisional surgery for locoregional recurrent melanoma - 44[-]5. Safety and efficacy of isolated limb perfusion in elderly melanomia patients - 58[-](Editorial) Isolated Limb Perfusion in Elderly Melanomia Patients - 70[-]6. Repeat isolated limb perfusion with TNFa and melphalan for recurrent limb melanoma after failure of previous perfusion - 72[-]7. Prognostic factors for poor survival after isolated limb perfusion: criteria for patient selection? - 84[-]8. Long-term results of a double perfusion schedule using high-dose hypertermia and melphalan sequentially in extensive melanoma of the lower limb - 94[-]9. Quality of life in long-term survivors of isolated limb perfusion for melanoma of the limbs - 104[-]10. Isolated limb perfusion with TNF-a and melphalan for unresectable soft tissue sarcoma of the extremities - 116[-]11. Isolated limb perfusion with melphalan for femoral metastases of breast cancer: case report - 128[-]12. Summary and conclusions/Samenvatting en conclusies - 134[-]Appendix.Regionale isolatieperfusie: ook bij bejaarde patiënten goed toepasbaar (Dutch) - 142[-]Dankwoord (Dutch) - 150[-]Curriculum Vitae (Dutch) - 153Deze titel is onderdeel van de OAPEN Library - http://www.oapen.org.