Contents - 6[-]Introduction - 8[-]Ch.2:THE INFLUENCE OF THE ORGANIC MATRIX ON DEMINERALIZATION OF BOVINE ROOT DENTIN IN VITRO - 18[-]Ch.3:DISCOLORATION OF DENTAL CARIES LESIONS: A REVIEW - 34[-]Ch.4:THE MAILLARD REACTION IN DEMINERALIZED DENTIN IN VITRO - 44[-]Ch.5:MODIFICATION OF AMINO ACID RESIDUES IN CARIOUS DENTIN MATRIX - 58[-]Ch.6:A NOVEL PYRROLENINONE CROSS-LINK FROM BOVINE DENTIN - 74[-]Ch.7:CONCLUDING REMARKS - 96[-]Dutch Summary - 100[-]Dutch epilog - 104Het laboratorium- en literatuuronderzoek in dit proefschrift betreft de mogelijke effecten van reacties van de organische matrix van dentine op cariës.