Scientific Challenges Today and Tomorrow has been published to mark the 225th anniversary of the Royal Natural Sciences Society in Groningen (KNG). This jubilee book brings together chapters written by a selection of leading researchers from the University of Groningen’s Faculty of Science & Engineering and from the University Medical Centre Groningen. They reflect on scientific progress in the fields of Energy & Environment; Artificial Intelligence; Life & Health; Prediction, Prevention & Care; the Universe; Personalized Medicine; Advanced Materials; and Health, Ageing & Disease.The book blends scientific advances with reflections on the Society’s distinguished history and reveals how today’s discoveries may help shape the future.Scientific Challenges Today and Tomorrow is an inspiring tribute to the Society’s enduring mission: stimulating curiosity, advancing knowledge, and connecting science and society—yesterday, today, and tomorrow.