The concept of ‘serendipity’ is traditonally associated with ‘luck’, ‘chance’ or ‘good fortune’, but the reality paints a very different picture and facts suggest otherwise: serendipity is not ‘luck’—our ‘unused braincapacity’ turns out to be our greatest cognitive power. The idea that the unconscious is the internal ‘AI supercomputer’ of the human mind, offers a fascinating perspective. Our unconsciousness operates beneath the surface, outside of our conscious awareness, much like a hyper-intelligent assistant running in the background. Serendipity is the dynamic of the interaction between our conscious (rational) brain and our unconscious (intuitive) brain. Our unconscious mind connects patterns and draws conclusions from years of collected data, experiences, lore and learning— but without interrupting our conscious focus. Research in neuroscience and psychology reveals that the unconsciousness handels far more than we know and we found out that we rely on our unconscious brain much more frequently—and at far more critical moments—than we tend to realize. This novel insight reframes serendipity (serendipity redefined) and it marks a shift in our understanding of serendipity. Serendipity 2.0 is the interplay between the conscious and unconscious mind, it is fundamental to human brain functioning and is crucial for our inventiveness, decision-making, and creativity.