As the sequel opens, we find our heroes, David and John, again embroiled in a series of horrifying yet mind-bogglingly ridiculous events caused primarily by their own gross incompetence. The guys find that books and movies about zombies may have triggered a zombie apocalypse, despite a complete lack of zombies in the world. As they race against the clock to protect humanity from its own paranoia, they must ask themselves, who are the real monsters? Actually, that would be the shape-shifting horrors secretly taking over the world behind the scenes that, in the end, make John and Dave kind of wish it had been zombies after all.